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samuel hom

T3 · host / generalist
4 calls·4 names·75% bull·last heard 4 months ago·TBPN
track record

no scored calls yet — needs a stated position or a categorical verdict, with a matured window vs SPY

top calls

highest conviction · one per company
1stmedium conviction
$SEMATIC-LABSSematic Labsposition

Sematic Labs cuts systematic reviews from years to four hours

Hom said Sematic Labs uses AI to automate steps in regulatory systematic reviews, reducing a process that can take years manually to roughly four hours.

TBPN2026-06episode →
2ndmedium conviction
$RVMDRevolution Medicines

Revolution Medicines doubles pancreatic-cancer survival and opens combination path

Hom said Revolution Medicines' molecular-glue therapy increased median survival in second-line metastatic pancreatic cancer from roughly seven to thirteen months, with fewer serious adverse events, and could become a baseline for combination therapies.

TBPN2026-06episode →
3rdmedium conviction
$LLYEli Lilly

Biotech patent cliff prevents $100T valuations: Lilly at $1T but tirzepatide faces 95% revenue drop post-patent

Unlike tech, pharma faces patent cliffs where generics erode 95% of revenue after ~20 years. Tirzepatide doing $51B sales but will decline. Manufacturing scale for $50B drugs creates moat but also capex burden. 100T biotech valuation unlikely without patent reform or new modalities.

TBPN2026-06episode →

most discussed · click a bar to filter

  • $RVMD
  • $SEMATIC-LABS
  • $LLY
  • $TNGX

recurring themes

  • AI Drug Discovery1
  • Life Sciences & Drug Development1
4 total
$RVMD
···
Revolution Medicines
MEDsamuel hom·TBPN·4 months ago·WWDC, Jobs Up Stocks Down, VC Horror Stories, Cars and Planes
Revolution Medicines doubles pancreatic-cancer survival and opens combination path
Hom said Revolution Medicines' molecular-glue therapy increased median survival in second-line metastatic pancreatic cancer from roughly seven to thirteen months, with fewer serious adverse events, and could become a baseline for combination therapies.
"They used a very innovative creative approach to drug the molecule using a molecular glue... able to double the median overall survival versus the standard of care chemotherapy...…"
103:18
$SEMATIC-LABS
Sematic Labs
MEDsamuel hom·TBPN·4 months ago·WWDC, Jobs Up Stocks Down, VC Horror Stories, Cars and Planes· position
Sematic Labs cuts systematic reviews from years to four hours
Hom said Sematic Labs uses AI to automate steps in regulatory systematic reviews, reducing a process that can take years manually to roughly four hours.
"One of the essential steps in the regulatory process is something called a systematic review... takes years. Currently it's done manually. We used AI to automate many of the steps…"
98:42
$LLY
···
Eli Lilly
MEDsamuel hom·TBPN·4 months ago·WWDC, Jobs Up Stocks Down, VC Horror Stories, Cars and Planes
Biotech patent cliff prevents $100T valuations: Lilly at $1T but tirzepatide faces 95% revenue drop post-patent
Unlike tech, pharma faces patent cliffs where generics erode 95% of revenue after ~20 years. Tirzepatide doing $51B sales but will decline. Manufacturing scale for $50B drugs creates moat but also capex burden. 100T biotech valuation unlikely without patent reform or new modalities.
"The biggest drug in the world today is tirzepatide which did about $51 billion of sales already this year... as it goes off patent then the generics come through and it will dwind…"
91:55
$TNGX
···
Tango Therapeutics
MEDsamuel hom·TBPN·4 months ago·WWDC, Jobs Up Stocks Down, VC Horror Stories, Cars and Planes
Tango combination improves survival beyond Revolution's pancreatic-cancer therapy
Hom said Tango Therapeutics added its drug to Revolution Medicines' therapy and improved survival further, supporting a combination-treatment path.
"There's a new drug from a company called Tango Therapeutics... they added their drug on top of Daramrazib and even improved the survival even further."
104:46
8
AI Drug Discoverytailwind
AI compressing 10-year drug development: systematic reviews 2yr→4hr, KRAS molecular glue, combo therapies
Sematic Labs automates systematic reviews (regulatory bottleneck). Revolution Medicines drugs 'undruggable' KRAS with molecular glue, doubling pancreatic cancer survival. Tango combos extend further. AI accelerating target ID, trial design, real-time FDA review (real-time trials). China running innovative trials faster/cheaper. Patent cliff pressure makes speed essential for pharma economics.
7
Life Sciences & Drug Developmentheadwind
Pharma patent cliffs prevent $100T valuations; manufacturing scale for $50B drugs creates capex moat
Unlike software, biologics face 95% revenue erosion post-patent. Tirzepatide ($51B) and semaglutide will face generic competition. Manufacturing at $50B scale requires specialized facilities (not just lab scale) creating barrier to entry. AI drug discovery helps but doesn't solve patent cliff. 100T valuation requires patent reform or platform companies with continuous pipeline replacement.