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$CRM · Curative cancels $600k/yr Salesforce contract, replaces with internal AI-built CRM in 2 months
now playing · $CRM
$CURATIVEbullish· high· posfred turner
Curative pivots from $5B COVID testing to AI-driven health insurance at $1.3B valuation
Curative is leveraging its pandemic-scale operations expertise and AI agents to disrupt the health insurance market by automating back-office workflows (credentialing, claims, und…
$SUBCRITICALbullish· high· posfred turner
Subcritical pursues energy amplifier nuclear fission with particle accelerator for inherent safety
Subcritical is commercializing the energy amplifier concept (accelerator-driven subcritical fission) which operates at 0.97 criticality — physically incapable of runaway reaction…
$Y-COMBINATORbullish· mediumfred turner
Y Combinator enabled UK founder's move to Silicon Valley and Curative's creation
YC's founder-friendly model (vs UK credential-based investing) allowed a 19-year-old UK founder to raise capital, iterate from cattle testing to sepsis to COVID to health insuranc…
$A16Zneutral· lowfred turner
a16z bio fund seeded first company (TL Biolabs/Shield) without TAM analysis
a16z's bio fund invested $1.65M in cattle testing company based on founder potential rather than market size — the company later pivoted to human diagnostics after Series A invest…
$RObearish· lowfred turner
Ro spent hundreds of millions on failed sepsis diagnostics — graveyard of capital-intensive diagnostics
Large capital investments in sepsis diagnostics (Ro, Siemens) failed because better tests don't help if community hospitals lack staff to suspect sepsis early — the bottleneck is…
$SIEMENS-HEALTHINEERS···bearish· lowfred turner
Siemens Healthineers spent $100M on failed sepsis diagnostics — workflow beats test accuracy
Large capital investments in sepsis diagnostics (Ro, Siemens) failed because better tests don't help if community hospitals lack staff to suspect sepsis early — the bottleneck is…
$JUSTIN-MATINEbullish· mediumfred turner
Justin Matine first investor in Curative at $3M valuation, got 10x return via dividend
Early conviction backing of founder (invested $125k at $3M pre) paid off — Curative returned 10x capital via dividend before insurance pivot, and investors retained equity for $1.…
$DGX···bearish· mediumfred turner
Quest and LabCorp's efficiency-optimized model fails under pandemic surge demand
Traditional lab incumbents (Quest, LabCorp) are built for steady-state efficiency (1% margin gains) and cannot scale 10x rapidly during demand surges because their supply chains,…
$LH···bearish· mediumfred turner
LabCorp's efficiency-optimized model fails under pandemic surge demand
Traditional lab incumbents (Quest, LabCorp) are built for steady-state efficiency (1% margin gains) and cannot scale 10x rapidly during demand surges because their supply chains,…
$BLUE-CROSSbearish· mediumfred turner
Blue Cross consolidation creates negotiating inefficiencies AI-native insurers can exploit
Ultra-consolidated payer markets (4 major players) create bilateral monopolies with hospital systems that inflate costs; AI-native entrants can undercut on admin expense (9% → nea…
$CRM···bearish· highfred turner
Curative cancels $600k/yr Salesforce contract, replaces with internal AI-built CRM in 2 months
Salesforce and similar SaaS platforms are being displaced by internal AI-built tools that integrate natively with agent workflows, cost less, and eliminate dedicated admin headcou…
$SENTRYneutral· mediumfred turner
Sentry persists as infrastructure-layer SaaS despite AI-driven SaaS consolidation
Developer infrastructure tools like Sentry that embed deeply into engineering workflows and become part of the technical stack are resistant to AI-driven replacement, unlike appli…
$UNH···bearish· mediumfred turner
Consolidated payers like UnitedHealth face structural margin pressure from AI-native competitors
Large incumbents (UnitedHealth, Blue Cross) cannot rapidly adopt AI agents due to organizational inertia — laying off 50k people to capture AI margins takes a decade, while AI-nat…
$ANTHROPICbullish· highfred turner
Anthropic could reach $10T valuation as AI agent workloads explode across enterprise
Anthropic's Claude models are becoming the default compute layer for enterprise AI agents — Curative's token spend 6x'd monthly to millions, and at 5x price it would still beat hu…
$LOOKER···bearish· mediumfred turner
Curative migrates off Looker to Snowflake using AI agents, cutting year-long project to months
Traditional BI tools like Looker are being replaced by AI-assisted migrations to modern data stacks (Snowflake) where agents automate dashboard conversion and data restructuring,…
$SNOW···bullish· mediumfred turner
Snowflake gains as Curative migrates from Looker for cheaper, AI-friendly analytics
Snowflake benefits from enterprises moving off legacy BI stacks and leveraging its platform for AI-agent-driven data transformation and visualization workflows.
$JOSH-BUCKLEYbullish· lowfred turner
Josh Buckley first check into Curative during YC, backed founder despite UK background
Early founder-backed investing (Josh Buckley) overcame geographic bias — invested in YC batch company despite founder's UK origin and lack of traditional credentials, illustrating…