TickerTain
TickerTain
NewsroomShortsPortfolioConvergence
NewsroomShortsPortfolioConvergence
←
▶ 30:30 · AI Drug Discovery · AI project management compresses biotech development timelines
episode briefing
All-In Podcast

Bryan Johnson: I Just Took the Most Powerful Dose of DMT in the World... Here's What It Was Like

2026-03-26 · 2 company · 6 thematic
sentiment
2 bull0 bear0 neu
speakers
bryan johnson

Technology entrepreneur who founded Braintree and later created Kernel and OS Fund. He leads Blueprint, a longevity initiative built around intensive health measurement and experimentation.

episode shorts · 2

Bryan Johnson did the world's strongest psychedelic drug... her…

DMT: The Best Longevity Protocol?

now playing · AI Drug Discovery
Longevity & Agingtailwindscore 8/10bryan johnson
5-MeO-DMT and psilocybin show metabolic reset and brain rejuvenation
Psychedelics act as longevity interventions by annihilating the default mode network, triggering neuroplasticity, reducing inflammation, and producing measurable metabolic resets (blood glu…
Longevity & Agingtailwindscore 7/10bryan johnson
Mitochondrial transplantation emerges as novel rejuvenation modality
Autologous mitochondrial transplantation using young donor mitochondria (maternally matched) coated in red blood cell envelopes for immune evasion represents a 'whole therapeutic modality n…
Longevity & Agingtailwindscore 8/10bryan johnson
FoxO3 plasmid therapy demonstrates 50%+ tissue rejuvenation in vivo
FoxO3 gene delivery via mesenchymal stem cells achieved over 50% tissue rejuvenation across multiple organs in preclinical studies — described as 'the best demonstration in the entire world…
AI Drug Discoverytailwindscore 6/10bryan johnson
AI project management compresses biotech development timelines
Johnson notes AI capabilities for managing complex biotech programs (gene therapy construction, trial design) have transformed 'so different now, 6 months later' — suggesting AI-accelerated…
Longevity & Agingtailwindscore 7/10bryan johnson
Patient-derived organoids enable in vitro drug screening before in the individual
Johnson has generated iPSC-derived organoids (heart, liver, lung) from his own cells to test molecules in vitro before self-administration — creating a personalized 'digital twin' platform…
Longevity & Agingtailwindscore 7/10bryan johnson
Computational Yamanaka factor discovery accelerates partial reprogramming
NewLimit's AI-driven computational approach has dramatically accelerated discovery of safe Yamanaka factor combinations and dosing regimens, solving the critical oncogenic risk of overdosin…